The Role of Insulin in Wound Healing Process: Mechanism of Action and Pharmaceutical Applications
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چکیده
Abbreviations: PI3K-Akt: Phosphatidylinositol-3-Kinase and Protein Kinase B; Rac1: Ras-Related C3 Botulinum Toxin Substrate 1; LN332: Laminin 332; EGF: Epidermal Growth Factor; EGF-R: Epidermal Growth Factor Receptor; IGF1&IGF-II: Insulin-Like Growth Factor 1&2; Gtpase: Guanosine 5’-Triphosphate Hydrolase Enzyme; IRS-1, IRS-2: Insulin Receptor Substrate 1&2; ERK: Extracellular Receptor Kinase; VEGF: Vasoactive Endothelial Growth Factor; SOS: The Son of Sevenless; Enos: Endothelial Nitric Oxide Synthase; SDF-1α: Stromal-Derived-Factor-1; MIP-2: Macrophage inflammation Protein 2
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